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Selective synthesis of either enantiomer of an anti-breast cancer agent via a common enantioenriched intermediate
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https://doi.org/10.1016/j.tetlet.2015.02.121Abstract
A stereoselective synthesis of a bioactive triarylmethane is described. Key to the synthesis is a nickel-catalyzed Suzuki-Miyaura coupling which proceeds with retention at the benzylic center. This method is complementary to our previously reported nickel-catalyzed Kumada coupling which proceeds with inversion. Together, the two methods allow for efficient access to either enantiomer of biologically relevant triarylmethanes from a common enantioenriched intermediate.
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