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First Successful Lung Transplantation for Sickle Cell Disease with Severe Pulmonary Arterial Hypertension and Pulmonary Veno‐Occlusive Disease
- George, M Patricia;
- Novelli, Enrico M;
- Shigemura, Norihisa;
- Simon, Marc A;
- Feingold, Brian;
- Krishnamurti, Lakshmanan;
- Morrell, Matthew R;
- Gries, Cynthia G;
- Haider, Syed;
- Johnson, Bruce A;
- Crespo, Maria M;
- Bhama, Jay K;
- Bermudez, Christian;
- Yousem, Samuel A;
- Toyoda, Yoshiya;
- Champion, Hunter C;
- Pilewski, Joseph M;
- Gladwin, Mark T
- et al.
Published Web Location
https://doi.org/10.1086/674749Abstract
Little is known about the use of lung transplantation in the management of sickle cell disease-associated pulmonary arterial hypertension (SCD-PAH). We present clinical and pathological data and report the first successful outcome of bilateral lung transplantation in a patient with severe SCD-PAH and pulmonary veno-occlusive disease (PVOD). We discuss the complexities of multidisciplinary planning and management of lung transplantation in patients with SCD-associated pulmonary vascular complications. This case reports the first documented successful lung transplant and first case of PVOD in a patient with SCD-PAH.
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