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Self-Assessed Severity as a Determinant of Coronavirus Disease 2019 Symptom Specificity: A Longitudinal Cohort Study
- Bershteyn, Anna;
- Dahl, Angela M;
- Dong, Tracy Q;
- Deming, Meagan E;
- Celum, Connie L;
- Chu, Helen Y;
- Kottkamp, Angelica C;
- Greninger, Alexander L;
- Hoffman, Risa M;
- Jerome, Keith R;
- Johnston, Christine M;
- Kissinger, Patricia J;
- Landovitz, Raphael J;
- Laufer, Miriam K;
- Luk, Alfred;
- Neuzil, Kathleen M;
- Paasche-Orlow, Michael K;
- Pitts, Robert A;
- Schwartz, Mark D;
- Stankiewicz Karita, Helen C;
- Thorpe, Lorna E;
- Wald, Anna;
- Zheng, Crystal Y;
- Wener, Mark H;
- Barnabas, Ruanne V;
- Brown, Elizabeth R
- et al.
Published Web Location
https://doi.org/10.1093/cid/ciac129Abstract
Coronavirus disease 2019 symptom definitions rarely include symptom severity. We collected daily nasal swab samples and symptom diaries from contacts of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) case patients. Requiring ≥1 moderate or severe symptom reduced sensitivity to predict SARS-CoV-2 shedding from 60.0% (95% confidence interval [CI], 52.9%-66.7%) to 31.5% (95% CI, 25.7%- 38.0%) but increased specificity from 77.5% (95% CI, 75.3%-79.5%) to 93.8% (95% CI, 92.7%-94.8%).
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