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Miscarriage and stillbirth following maternal Zika virus infection in nonhuman primates
- Dudley, Dawn M;
- Van Rompay, Koen K;
- Coffey, Lark L;
- Ardeshir, Amir;
- Keesler, Rebekah I;
- Bliss-Moreau, Eliza;
- Grigsby, Peta L;
- Steinbach, Rosemary J;
- Hirsch, Alec J;
- MacAllister, Rhonda P;
- Pecoraro, Heidi L;
- Colgin, Lois M;
- Hodge, Travis;
- Streblow, Daniel N;
- Tardif, Suzette;
- Patterson, Jean L;
- Tamhankar, Manasi;
- Seferovic, Maxim;
- Aagaard, Kjersti M;
- Martín, Claudia Sánchez-San;
- Chiu, Charles Y;
- Panganiban, Antonito T;
- Veazey, Ronald S;
- Wang, Xiaolei;
- Maness, Nicholas J;
- Gilbert, Margaret H;
- Bohm, Rudolf P;
- Adams Waldorf, Kristina M;
- Gale, Michael;
- Rajagopal, Lakshmi;
- Hotchkiss, Charlotte E;
- Mohr, Emma L;
- Capuano, Saverio V;
- Simmons, Heather A;
- Mejia, Andres;
- Friedrich, Thomas C;
- Golos, Thaddeus G;
- O’Connor, David H
- et al.
Published Web Location
https://doi.org/10.1038/s41591-018-0088-5Abstract
Zika virus (ZIKV) infection is associated with congenital defects and pregnancy loss. Here, we found that 26% of nonhuman primates infected with Asian/American ZIKV in early gestation experienced fetal demise later in pregnancy despite showing few clinical signs of infection. Pregnancy loss due to asymptomatic ZIKV infection may therefore be a common but under-recognized adverse outcome related to maternal ZIKV infection.
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