Ahiawodzi, Peter D; Kerber, Richard A; Taylor, Kira C; Groves, Frank D; O'Brien, Elizabeth; Ix, Joachim H; Kizer, Jorge R; Djoussé, Luc; Tracy, Russell P; Newman, Anne B; Siscovick, David S; Robbins, John; Mukamal, Kenneth

doi:10.1080/1354750x.2016.1276966

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Sleep-disordered breathing is associated with higher carboxymethyllysine level in elderly women but not elderly men in the cardiovascular health study

2017

Published Web Location

https://doi.org/10.1080/1354750x.2016.1276966

Abstract

Context

Carboxymethyl-lysine (CML) results from oxidative stress and has been linked to cardiovascular disease.

Objective

The objective of this study is to investigate the association between sleep-disordered breathing (SDB) - a source of oxidative stress - and CML.

Materials and methods

About 1002 participants in the Cardiovascular Health Study (CHS) were studied.

Results

Women with SDB had significantly higher CML concentration compared with those without SDB (OR = 1.63, 95%CI = 1.03-2.58, p = 0.04). The association was not significant among men.

Discussion

SDB was associated with CML concentration among elderly women but not men in the Cardiovascular Health Study.

Conclusion

Accumulation of CML may be an adverse health consequence of SDB.

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