- Ahiawodzi, Peter D;
- Kerber, Richard A;
- Taylor, Kira C;
- Groves, Frank D;
- O'Brien, Elizabeth;
- Ix, Joachim H;
- Kizer, Jorge R;
- Djoussé, Luc;
- Tracy, Russell P;
- Newman, Anne B;
- Siscovick, David S;
- Robbins, John;
- Mukamal, Kenneth
Context
Carboxymethyl-lysine (CML) results from oxidative stress and has been linked to cardiovascular disease.Objective
The objective of this study is to investigate the association between sleep-disordered breathing (SDB) - a source of oxidative stress - and CML.Materials and methods
About 1002 participants in the Cardiovascular Health Study (CHS) were studied.Results
Women with SDB had significantly higher CML concentration compared with those without SDB (OR = 1.63, 95%CI = 1.03-2.58, p = 0.04). The association was not significant among men.Discussion
SDB was associated with CML concentration among elderly women but not men in the Cardiovascular Health Study.Conclusion
Accumulation of CML may be an adverse health consequence of SDB.